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What is 5-MeO-DMT?

ORDER 5 MEO DMT Important: Although 5-MeO-DMT and DMT are chemically similar, they have different effects and safety profiles from each other, so please do not substitute 5-MeO-DMT for DMT. They should be viewed as entirely different chemicals and treated as such.

5-MeO-DMT, sometimes referred to as "The God Molecule", is a psychedelic of the tryptamine class. It occurs naturally in a variety of plant species, and at least one species of toad - the Sonoran desert toad (for more information on this subject we recommend Hamilton Morris  ' booklet  "Bufo Alvarius: The Psychedelic Toad of the Sonoran Desert").

It is closely related to DMT and 5-HO-DMT and has traditionally been used as an entheogen in tribal ceremonies in South America.

5-MeO-DMT has surged in popularity in recent years as many anecdotal reports have come to light about its potential as a healing agent. Mainstream media such as  Forbes  have also shed some light on the healing potential of this chemical.

While research on 5-MeO-DMT is limited, some studies have supported this anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported lower levels of depression and anxiety, and higher levels of life satisfaction and mindfulness. The effects lasted at least four weeks when a follow-up visit was completed.

Another study surveyed 362 people who had taken 5-MeO-DMT and found that 80% of respondents reported improvements in anxiety and depression.

What are the effects of 5-MeO-DMT?

It is believed that the psychedelic effects of 5-Meo-DMT are primarily due to its effectiveness as a partial agonist at the 5-HT2A receptor. In particular, it shows high binding affinity for the 5-HT2A and 5-HT1A subtypes. Not much is known about these interactions, however, so our understanding of how they lead to the psychedelic experience is currently limited.

5-MeO-DMT is also thought to inhibit the reuptake of the neurotransmitters serotonin, norepinephrine, and dopamine, but little is known about the role of these mechanisms. Therefore, it is strongly recommended to avoid combinations with SSRIs, SRIs, MAOIs, RIMAs or other substances that act as releasing agents or reuptake inhibitors of monoamine neurotransmitters (e.g. serotonin and dopamine).

Some of the most commonly reported effects are:

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